Senna and Vayne Interactions
Senna has 1 line about Vayne, and Vayne answers with 2. They're grouped below by what sets each one off, with both sides together.
First encounter
Senna to Vayne
First Encounter › First Encounter with Vayne
- "Vayne, you can aim for my heart when you find your own."
Vayne to Senna
Sentinel: First Encounter › First Encounter with Senna
- "Senna. Not like you to choose the wrong side."
Kills
Read the rest
Every line is quoted as the wiki transcribes it. Voice lines belong to Riot Games.
Senna's lines are licensed CC BY-SA 3.0, from the League of Legends Wiki's revision 4041341 (July 8, 2026).
Vayne's lines are licensed CC BY-SA 3.0, from the League of Legends Wiki's revision 4023141 (May 28, 2026).